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greatly from those cited by others. In part, this appears to be due to differences in the areas sampled
and/or the tissues that are considered to be part of the skin, but also appears to be due to the
methodology employed to make such measurements. Measurement techniques have included
measuring the thickness of skin folds, microscopically examining sectioned skin, radiography, and,
more recently, ultrasound. The ultrasound technique has been continuously refined and appears
to have allowed for the most precise measurements.
In general, the thickness of the skin has been found to vary throughout the body (Southwood, 1955;
Goldsmith, 1983; Fornage and Deshayes, 1986; Wysocki, 1999; Rayan and Akelman, 2011).
Recent sonographic analyses of the skin have concluded that skin thickness increases at puberty
and starts to become thinner again after the second decade (Tan et al., 1982; de Rigal et al., 1989;
Seidenari et al., 1994). Skin thickness is also known to increase as a result of exposure to the sun
(Richard et al., 1994). In general, the skin of men is thicker than that of women (Southwood, 1955;
Alexander and Miller, 1979; Tan et al., 1982; Fornage and Deshayes, 1986; Seidenari et al., 1994).
Aged skin (the skin of someone in at least their sixth decade) is atrophic (in a state of deterioration),
making it transparent and less elastic, and allowing the vasculature to become more apparent
(Montagna and Carlisle, 1979; de Rigal et al., 1989; Gilchrest, 1996). In addition to a thinning of
both the epidermal and dermal layers with aging, the junction between the layers flattens, making
the skin more fragile (Gilchrest, 1996; Baumann, 2007). A decrease in the vascularity of the
dermis with aging and a reduction in the activity of fibroblasts (see below) results in prolonged
wound healing (Gilchrest, 1996).
The thinner and more superficial of the two skin layers, the epidermis (also called the cutaneous
layer), serves as the body’s first line of defense against injury. It is avascular (lacking blood
vessels) and contains no nerve endings; it is dependent on the underlying dermis for both nutrition
and oxygen (Marble, 1960; Wysocki, 1999; Trott, 2005). The epidermis is a stratified epithelium
that is made up of four or five layers (depending on its location in the body). In a constant state
of turn-over, cell division occurring at the deepest level results in the migration of cells outward,
eventually reaching the outermost layer over a period of weeks, where they are ultimately shed to
the environment (Goldsmith, 1983). The majority of the cells that make up the epidermis produce
the protein keratin. When cells reach the surface, engorged with keratin, they eventually die.
Between the epidermis and dermis is a thin basement membrane, essentially a firm mesh of fibers
(Marble, 1960). Directly below, and attached firmly to the basement membrane, is the dermis,
which is also called the cutis. The dermis represents the next line of defense against injury to the
skin. It is both vascularized and innervated, providing both the blood vessels and nerves that
supply the epidermis; the red or blue hue of the skin arises from this layer and the amount of
oxygenated, versus deoxygenated, hemoglobin within the vascular network (Marble, 1960;
Wysocki, 1999). In addition to sensory nerve endings, the dermis contains hair follicles, sweat
glands, sebaceous glands, and lymphatics.
The dermis is many times thicker than the epidermis and represents the majority of the thickness
of the skin. Unlike the epidermis, the dermis contains few cells; its thickness is due to connective
tissue rather than cells. The main cell type found in the dermis is the fibroblast, which produces
both collagen and elastin (Wysocki, 1999). Collagen is the principal structural component of skin
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